We note that an increase in transnational drug trafficking activity, through the Mexican cartels, is threatening, to varying degrees, the national security of Colombia, Peru and Bolivia. As a result of this, in Andean subregional security policy, with the support of the United States, a new multilateral antidrug strategy must be formulated that can successfully confront the new levels of drug trafficking and criminal violence practiced by stateless transnational players, such as the Mexican cartels in the Andean region.