This essay analyzes the relations between the People's Republic of China (PRC) and Colombia in the strategic context of the region. It begins with an analysis of why growing relations between China and the region are a key security and defense issue, despite the mainly economic nature of the relationship. It continues with an analysis of China's strategic interests in Colombia within the framework of general interests in the region, which include access to primary products, access to markets, isolating Taiwan, and fostering a secure environment for China's rise in the world. He concludes that relations between Colombia and the People's Republic of China in recent years have been primarily commercial in nature, with multiple strategic implications for Colombia, including the evolution of its trade structure, the increase in human trafficking, and the indirect empowerment of irregular forces and external threats in its neighborhood, and that China-Colombia-US relations should be understood as a triangle in which the development of one party impacts the others, but with opportunities to collaborate, including defense and criminality issues that involve the entire region.