This presentation analyzes the subject of secession, establishing its characteristics and proposing, as a hypothesis, that these theoretical considerations could be taking shape in the Bolivian reality of today. The author makes a qualitative assessment of the country's most serious problems as a function of the aforementioned hypothesis. The presentation seeks to identify the underground forces undermining territorial cohesion in Latin America today, and emphasizes ethnoindigenism as an explanatory variable. The author utilizes historical examples of secessions in other parts of Latin America, and in Bolivia itself, with the idea of establishing similarities and differences with the case under study. The objective is to demonstrate that centrifugal dynamics have already taken shape, which are currently having repercussions on the stability and governability of this regional space and which, put into a comparative perspective with empirical evidence, could be irreversible in nature.