The COVID-19 pandemic has upended the post-World War II political, economic, social and international order with many questioning whether our current democratic and economic institutions are suitable for and capable of recovering from this profound health, economic and governance crisis. While democracies and open economies were hard hit by the pandemic, illicit networks including transnational criminal groups, terrorist organizations and their facilitators have proven more resilient, expanding their activities and influence in the Americas. This article will examine the impact COVID-19 has had on the health, economy, democracy, security of the region and on illicit networks. The article will conclude with recommendations on how nations incorporate strategic foresight and anticipatory governance to safeguard their sovereignty and counter to the growing threats from corruption and illicit networks in the new world order.