Transnational organized crime (TOC) in Latin America represents a formidable threat to national security. These illicit groups have operated in the Western Hemisphere for decades. Recently, however, the speed and violence associated with these non-state groups have exacerbated the magnitude of the problems to alarming levels. Criminal groups are not limited only to trafficking narcotics. They also operate human trafficking networks, illegal arms trafficking, engage in extortion, cybercrime, and political intimidation. This undermines security, generates instability, and scares away foreign investment and tourism. This essay examines initiatives underway in the Western Hemisphere to address the convergence of transnational organized crime and other illicit networks. It also provides suggestions for implementing more effective strategies to deal with illegal groups whose evolution threatens the national security of the United States and its allies.